abstract：:Lysosomal storage diseases are a heterogeneous group of hereditary disorders characterized by a deficiency in lysosomal function. Although these disorders differ in their etiology and phenotype those that affect the nervous system generally manifest as a profound deterioration in neurologic function with age. Over the...

journal_title：Brain research

authors： Phinney DG,Isakova IA

更新日期：2014-07-21 00:00:00

abstract：:Dendritic spines are actin-rich protrusions from the dendritic shaft, considered to be the locus where most synapses occur, as they receive the vast majority of excitatory connections in the central nervous system (CNS). Interestingly, hippocampal spines are plastic structures that contain a dense array of molecules i...

journal_title：Brain research

authors： Bellot A,Guivernau B,Tajes M,Bosch-Morató M,Valls-Comamala V,Muñoz FJ

更新日期：2014-07-21 00:00:00

abstract：:Dynamic microvascular remodeling maintains an optimal continuous supply of oxygen and nutrients to the brain to account for prolonged environmental variations. The objective of this study was to determine the relative time course of capillary regression during re-oxygenation after exposure to prolonged moderate hypoxi...

journal_title：Brain research

authors： Benderro GF,LaManna JC

更新日期：2014-06-20 00:00:00

abstract：:Converging evidence implicates alterations in multiple signaling pathways in the etiology of schizophrenia. Previously, these studies were limited to the analysis of one or a few phosphoproteins at a time. Here, we use a novel kinase array platform to simultaneously investigate the convergence of multiple signaling ca...

journal_title：Brain research

authors： McGuire JL,Hammond JH,Yates SD,Chen D,Haroutunian V,Meador-Woodruff JH,McCullumsmith RE

更新日期：2014-06-03 00:00:00

abstract：:Patients undergoing dental treatment employ different attentional strategies. In order to investigate associated neuronal correlates, we exposed 20 women suffering from dental phobia and 20 non-anxious women to disorder-related and unrelated pictures. They were asked to either direct their attention to a foreground st...

journal_title：Brain research

authors： Scharmüller W,Ubel S,Leutgeb V,Schoengassner F,Wabnegger A,Schienle A

更新日期：2014-05-30 00:00:00

abstract：:[d-Ala(2)-d-Leu(5)]-Enkephalin (DADLE) has shown promising results in protecting neurons from damages. However, the mechanism for this protection is still under investigation. The current study was carried out to test the hypothesis that DADLE may regulate cellular transcription in neurons. SH-SY5Y cells and primary c...

journal_title：Brain research

authors： Tian J,Gu Y,Sun K,Wang B,Chen J,Wang X,Su D

更新日期：2014-05-27 00:00:00

abstract：:Manipulations of either discrete emotions (e.g. happiness) or affective dimensions (e.g. positivity) have a long tradition in emotion research, but interactive effects have never been studied, based on the assumption that the two underlying theories are incompatible. Recent theorizing suggests, however, that the human...

journal_title：Brain research

authors： Briesemeister BB,Kuchinke L,Jacobs AM

更新日期：2014-05-20 00:00:00

abstract：:Modern lifestyle exposes nearly all humans to electromagnetic fields, particularly to extremely low frequency electromagnetic fields (ELF-EMFs). Prolonged exposure to ELF-EMFs induces persistent changes in neuronal activity. However, the modulation of synaptic efficiency by ELF-EMFs in vivo is still unclear. In the pr...

journal_title：Brain research

authors： Komaki A,Khalili A,Salehi I,Shahidi S,Sarihi A

更新日期：2014-05-20 00:00:00

abstract：:Beta-amyloid (Aβ)-mediated inflammation plays a critical role in the initiation and progression of Alzheimer׳s disease (AD). Anti-inflammatory treatment may provide therapeutic benefits. In this study, the effect of hydroxy-safflor yellow A (HSYA) on Aβ1-42-induced inflammation in AD mice was investigated and the unde...

journal_title：Brain research

authors： Zhang ZH,Yu LJ,Hui XC,Wu ZZ,Yin KL,Yang H,Xu Y

更新日期：2014-05-14 00:00:00

abstract：:The current study was performed to evaluate the mechanisms and therapeutic effects of overexpressing neuroglobin (Ngb) on spinal cord injury (SCI). Adeno-associated virus (AAV) was injected in the T12 section 7 days before SCI. Animals were randomly divided into four groups: a sham group, a vehicle group, an AAV-EGFP ...

journal_title：Brain research

authors： Lan WB,Lin JH,Chen XW,Wu CY,Zhong GX,Zhang LQ,Lin WP,Liu WN,Li X,Lin JL

更新日期：2014-05-08 00:00:00

abstract：:17β-Estradiol is a multi-active steroid that imparts neuroprotection via diverse mechanisms of action. However, its role as a neuroprotective agent after spinal cord injury (SCI), or the involvement of the estrogen receptor-alpha (ER-α) in locomotor recovery, is still a subject of much debate. In this study, we evalua...

journal_title：Brain research

authors： Mosquera L,Colón JM,Santiago JM,Torrado AI,Meléndez M,Segarra AC,Rodríguez-Orengo JF,Miranda JD

更新日期：2014-05-02 00:00:00

abstract：:Behavioral studies have shown that emotional facial expressions are detected more rapidly and accurately than are neutral expressions. However, the neural mechanism underlying this efficient detection has remained unclear. To investigate this mechanism, we measured event-related potentials (ERPs) during a visual searc...

journal_title：Brain research

authors： Sawada R,Sato W,Uono S,Kochiyama T,Toichi M

更新日期：2014-04-29 00:00:00

abstract：:β-Amyloid peptide (Aβ) plays a central role in the pathogenesis of Alzheimer׳s disease, but in lower amounts it is found in normal brains where it participates in physiological processes and probably regulates synaptic plasticity. This study investigated the effects of physiologically relevant concentrations of Aβ (1 ...

journal_title：Brain research

authors： Bukanova JV,Sharonova IN,Skrebitsky VG

更新日期：2014-04-16 00:00:00

abstract：:Febrile seizure (FS) remains the most common childhood neurological emergency. Although many studies have been done, controversy exists as to whether these seizures are associated with a significant risk for cognitive impairment. The aim of our study is to check whether there is a spatial learning and memory deficit i...

journal_title：Brain research

authors： Xiong Y,Zhou H,Zhang L

更新日期：2014-04-04 00:00:00

abstract：:Until recently, the bulk of research on the human reward system was focused on studying the dopaminergic and opioid neurotransmitter systems. However, extending the initial data from animal studies on reward, recent pharmacological brain imaging studies on human participants bring a new line of evidence on the key rol...

journal_title：Brain research

authors： Macoveanu J

更新日期：2014-03-27 00:00:00

abstract：:Platelet-derived growth factor-B (PDGF-B) is a growth factor that regulates cell migration, proliferation, and differentiation, and is involved in several physical and pathological processes. The overexpression of PDGF-B in glioma surgical samples revealed its effect on tumorigenesis. In this study, we determined that...

journal_title：Brain research

authors： Zhou Y,Jin G,Mi R,Dong C,Zhang J,Liu F

更新日期：2014-03-27 00:00:00

abstract：:Pro-social lying, which serves to benefit listeners, is considered more socially and morally acceptable than anti-social lying, which serves to harm listeners. However, it is still unclear whether the neural mechanisms underlying the moral judgment of pro-social lying differ from those underlying the moral judgment of...

journal_title：Brain research

authors： Hayashi A,Abe N,Fujii T,Ito A,Ueno A,Koseki Y,Mugikura S,Takahashi S,Mori E

更新日期：2014-03-27 00:00:00

abstract：:A reduction in adenosine deaminase acting on RNA 2 (ADAR2) activity causes the death of spinal motor neurons specifically via the GluA2 Q/R site-RNA editing failure in sporadic amyotrophic lateral sclerosis (ALS). We studied, over time, the spinal cords of ADAR2-knockout mice, which are the mechanistic model mice for ...

journal_title：Brain research

authors： Sasaki S,Takenari Yamashita,Hideyama T,Kwak S

更新日期：2014-03-06 00:00:00

abstract：:Lavender belongs to the family Labiatae and has a variety of cosmetic uses as well as therapeutic purposes in herbal medicine. The present study was conducted to evaluate the protective effect of lavender oil against brain edema and its possible mechanisms in an experimental model of stroke. Under Laser-Doppler Flowme...

journal_title：Brain research

authors： Vakili A,Sharifat S,Akhavan MM,Bandegi AR

更新日期：2014-02-22 00:00:00

abstract：:Pathophysiological responses to peripheral nerve injury include alterations in the activity, intrinsic membrane properties and excitability of spinal neurons. The intrinsic excitability of α-motoneurons is controlled in part by the expression, regulation, and distribution of membrane-bound ion channels. Ion channels, ...

journal_title：Brain research

authors： Romer SH,Dominguez KM,Gelpi MW,Deardorff AS,Tracy RC,Fyffe RE

更新日期：2014-02-14 00:00:00

abstract：:Inhibition of Aβ production and clearance of senile plaques have been considered as potential strategies in the treatment of Alzheimer's disease (AD). Activated protein C (APC) is an important factor in the anticoagulant system. However, whether APC can influence the condition of a chronic neurodegenerative process, s...

journal_title：Brain research

authors： Li B,Yu D,Xu Z

更新日期：2014-01-30 00:00:00

abstract：:Dynamin-1 is a multi-domain GTPase that is crucial for the fission stage of synaptic vesicle recycling and vesicle trafficking. In this study, we constructed prokaryotic expression plasmids for the four functional domains of dynamin-1, which are pGEX-4T-2-PH, pGEX-4T-2-PRD, pGEX-4T-2-GED and pGEX-4T-2-GTPase. Glutathi...

journal_title：Brain research

authors： Zhang C,Omran AG,He F,Deng X,Wu L,Peng J,Yin F

更新日期：2014-01-16 00:00:00

abstract：:During aging, estrogen production and circulating levels of estrogen are markedly decreased in females. Although several differences exist in the process of reproductive aging between women and female rats, the results of many studies suggest that the female rat, especially the middle-aged or aged ovariectomized femal...

journal_title：Brain research

authors： Yamaguchi N,Yuri K

更新日期：2014-01-16 00:00:00

abstract：:In rat models of absence epilepsy, epileptic spike-wave discharges appeared in EEG spontaneously, and the incidence of epileptic activity increases with age. Spike-wave discharges and sleep spindles are known to share common thalamo-cortical mechanism, suggesting that absence seizures might affect some intrinsic prope...

journal_title：Brain research

authors： Sitnikova E,Hramov AE,Grubov V,Koronovsky AA

更新日期：2014-01-16 00:00:00

abstract：:Leukocyte behavior in the cerebral microvasculature following vessel occlusion has not been fully elucidated. The purpose of this study was to investigate the effects of cilostazol on leukocyte behavior (rolling and adhesion) in murine cerebral microvessels following transient bilateral carotid artery occlusion using ...

journal_title：Brain research

authors： Fukuoka T,Hayashi T,Hirayama M,Maruyama H,Tanahashi N

更新日期：2014-01-16 00:00:00

abstract：:The roles of spinal N-methyl-d-aspartic acid receptor 2B (NR2B) subunit in central sensitization of chronic visceral pain were investigated. A rat model with irritable bowel syndrome (IBS) was established by colorectal distention (CRD) on post-natal days 8-14. Responses of the external oblique muscle of the abdomen to...

journal_title：Brain research

authors： Luo XQ,Cai QY,Chen Y,Guo LX,Chen AQ,Wu ZQ,Lin C

更新日期：2014-01-13 00:00:00

abstract：:Accumulating evidence indicates that extensive microglia activation-mediated local inflammation contributes to neuronal injury in cerebral ischemia. We have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), a potent volume-regulated anion channel (VRAC) inhibitor, s...

journal_title：Brain research

authors： Han Q,Liu S,Li Z,Hu F,Zhang Q,Zhou M,Chen J,Lei T,Zhang H

更新日期：2014-01-13 00:00:00

abstract：:The two primary categories of stroke, ischemic and hemorrhagic, both have fundamentally different mechanisms and thus different treatment options. These two stroke categories were applied to rat models to identify potential biomarkers that can distinguish between them. Ischemic stroke was induced by middle cerebral ar...

journal_title：Brain research

authors： Ren C,Zoltewicz S,Guingab-Cagmat J,Anagli J,Gao M,Hafeez A,Li N,Cao J,Geng X,Kobeissy F,Mondello S,Larner SF,Hayes RL,Ji X,Ding Y

更新日期：2013-12-02 00:00:00

abstract：:Expertise offers a unique insight into how our brain functions. The purpose of this experiment was to determine if motor system activity and functional connectivity between the cognitive system and sensorimotor system is differentially modulated by an individual's level of expertise. This goal was achieved through the...

journal_title：Brain research

authors： Tomasino B,Maieron M,Guatto E,Fabbro F,Rumiati RI

更新日期：2013-12-02 00:00:00

abstract：:Cerebellar granule neuronal cultures have been used to study the molecular mechanisms underlying neuronal functions, including neuronal morphogenesis. However, a limitation of this system is the difficulty to analyze isolated neurons because these are required to be maintained at a high density. Therefore, in the pres...

journal_title：Brain research

authors： Kubota K,Seno T,Konishi Y

更新日期：2013-11-20 00:00:00

abstract：:Training can induce significant changes in brain functioning and behavioral performance. One consequence of training is changing the pattern of brain activation. Abacus training is of interest because abacus experts gain the ability to handle digits with unusual speed and accuracy. However, the neural correlates of nu...

journal_title：Brain research

authors： Li Y,Hu Y,Zhao M,Wang Y,Huang J,Chen F

更新日期：2013-11-20 00:00:00

abstract：:In the context of injury to the corticospinal tract (CST), brainstem-origin circuits may provide an alternative system of descending motor influence. However, subcortical circuits are largely under subconscious control. To improve volitional control over spared fibers after CST injury, we hypothesized that a combinati...

journal_title：Brain research

authors： Harel NY,Yigitkanli K,Fu Y,Cafferty WB,Strittmatter SM

更新日期：2013-11-13 00:00:00

abstract：:Glioblastoma stem cells (GSCs) are thought to contribute to the diffuse invasiveness of malignant gliomas. Emerging evidence supports a role for a disintegrin and metalloproteinase 17 (ADAM17) in proteolytic ectodomain shedding of several EGFR-binding ligands, which subsequently activate PI3K/AKT and MEK/ERK pathways ...

journal_title：Brain research

authors： Chen X,Chen L,Chen J,Hu W,Gao H,Xie B,Wang X,Yin Z,Li S,Wang X

更新日期：2013-11-13 00:00:00

abstract：:Increasing evidence shows that exposure to an enriched environment (EE) after cerebral ischemia/reperfusion injury is neuroprotective in animal models. Recent studies have demonstrated that animals housed in an enriched environment condition after an experimental stroke obtained a better functional outcome than those ...

journal_title：Brain research

authors： Yu K,Wu Y,Hu Y,Zhang Q,Xie H,Liu G,Chen Y,Guo Z,Jia J

更新日期：2013-11-13 00:00:00

abstract：:Different mechanisms have been suggested to contribute to isoflurane-mediated neuroprotection. Previous studies have suggested that the protein Slit can abrogate neuronal death in mixed neuronal-glial cultures exposed to oxygen-glucose deprivation (OGD) and reperfusion (OGD/R). We hypothesized that isoflurane increase...

journal_title：Brain research

authors： Zhao XC,Zhang LM,Li Q,Tong DY,Fan LC,An P,Wu XY,Chen WM,Zhao P,Wang J

更新日期：2013-11-06 00:00:00

abstract：:Frequency modulation (FM) is an important building block of complex sounds that include speech signals. Exploring the neural mechanisms of FM coding with computer modeling could help understand how speech sounds are processed in the brain. Here, we modeled the single unit responses of auditory neurons recorded from th...

journal_title：Brain research

authors： Chang TR,Chiu TW,Sun X,Poon PW

更新日期：2013-11-06 00:00:00

abstract：:Cannabinoids are promising therapies to support neurogenesis and decelerate disease progression in neuroinflammatory and degenerative disorders. Whether neuroprotective effects of cannabinoids are sustainable during persistent viral infection of the CNS is not known. Using a rodent model of chronic viral encephalitis ...

journal_title：Brain research

authors： Solbrig MV,Fan Y,Hazelton P

更新日期：2013-11-06 00:00:00

abstract：:Growth cones integrate a remarkably complex concert of chemical cues to guide axons to their appropriate destinations. Recent work suggests that integrins contribute to axon guidance by interacting with a wide range of extracellular molecules including axon guidance molecules, by mechanisms that are not fully understo...

journal_title：Brain research

authors： Lemons ML,Abanto ML,Dambrouskas N,Clements CC,Deloughery Z,Garozzo J,Condic ML

更新日期：2013-11-06 00:00:00

abstract：:In this study we investigated the functional connectivity in 23 Mild TBI (mTBI) patients with and without memory complaints using resting state fMRI in the sub-acute stage of injury as well as a group of control participants. Results indicate that mTBI patients with memory complaints performed significantly worse than...

journal_title：Brain research

authors： Sours C,Zhuo J,Janowich J,Aarabi B,Shanmuganathan K,Gullapalli RP

更新日期：2013-11-06 00:00:00

abstract：:Hereditary Cystatin C Amyloid Angiopathy (HCCAA) is a rare genetic disease in Icelandic families caused by a mutation in the cystatin C gene, CST3. HCCAA is classified as a cerebral amyloid angiopathy and mutant cystatin C forms amyloid deposits in cerebral arteries resulting in fatal haemorrhagic strokes in young adu...

journal_title：Brain research

authors： Snorradottir AO,Isaksson HJ,Kaeser SA,Skodras AA,Olafsson E,Palsdottir A,Bragason BT

更新日期：2013-10-16 00:00:00